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ROS promotes receptor interacting serine/threonine kinase 3 (RIP3) phosphorylation, which subsequently triggers downstream mixed lineage kinase domain-like pseudokinase (MLKL) phosphorylation and activates MLKL translocation to the plasma membrane, increasing membrane permeability and inducing necrotic death in HCC tumor cells [125]

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This group was initially defined for its morphology and understood merely as a secondary component of histoarchitecture

By implementing such a comprehensive approach, we can mitigate the potential for conflicting results between studies 71,72,73 and, consequently, re-evaluate the presence of m 6 A modifications in other cytoplasmic-replicating RNA viruses