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The concerted action of the antioxidant defense system sensitively controls ROS levels within physiological limits

Cancers (Basel) (2014) 6(3):144163

In parallel, inhibition(s) on the non-oxidative phase of the pentose phosphate pathway can be alleviated by the provision of fructose-6-phosphate and/or glyceraldehyde-3-phosphate, both originating from glycolysis

*Correspondence: Hongwei Guo, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The enzyme also has a mitochondrial isoform that mediates the apoptotic response to oxidative stress49 and has a peroxidase independent structural role in sperm maturation.45, 50 GPx5 from both humans and rodents and Rodent GPx6 differ from other glutathione peroxidases in that their activities are independent of Selenium.51 This invariably implies that these forms of GPx may not be able to effectively scavenge H2O2, a feature which is characteristic of the selenium-dependent glutathione peroxidases.52 The clinical importance of GPx has been underlined by a number of studies