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14 Ferroptosis signaling pathways SLC7A11/GPX4 axis SLC7A11, also known as xCT, together with heavy chain subunit Solute Carrier Family 3 Member 2 (SLC3A2) form cystine-glutamate acid reverse transporter (System Xc - ), mediating the exchange of intracellular glutamate with extracellular cystine at 1:1

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