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BrzezinskiAVangelMGWurtmanRJNorrieGZhdanovaIBen-ShushanAet alEffects of exogenous melatonin on sleep: a meta-analysis

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That's the kind of evidence base that earns regulatory approval

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The researchers propose that DSIPs observed effects, particularly the selective increase in V3 and ADP/t without affecting VDNP, suggest that it does not stimulate the activity of respiratory chain enzymes or substrate transporters, as these would typically affect VDNP