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Chaetocin did not significantly affect DR5 mRNA expression, suggesting that chaetocin upregulated DR5 expression post-transcriptionally (Fig

GSH can be toxic, especially in cases of ascorbate deficiency, and these effects may be demonstrated in, for example, ascorbate deficient guinea pigs given 3.75 mmol/kg daily (1 ,152 mg/kg daily) in three divided doses, whereas in non-ascorbate deficient animals, toxicity was not seen at this dose, but were seen at double this dose