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This oxidative insult has been demonstrated to impair pancreatic -cell function and exacerbate insulin resistance, thereby contributing to the progression of T2DM [310]

33 Mice lacking the gene encoding Atox1 are observed to be perinatal lethal due to impaired Cu balance, which likely reflects the central role that this chaperone plays in Cu transport and homeostasis

They also carry the risks inherent to any surgical procedure, require recovery time, and demand lifelong nutritional follow-up

The incidence of IPF ranges from 0.9 to 9.3 cases/100,000 per year in Europe and North America, and from 3.5 to 13.0 cases/100,000 per year in Asia and South America [4]

Drach J, Leahy J, Goodacre A, Drach D, Sanchez-Williams G, Weier HU, Pinkel D, Andreeff M