(Dr.) Arun Karnwal, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, India and Prof
10.1111/j.1471-4159.1989.tb09150.x [DOI] [PubMed] [Google Scholar] Rodriguez R., Redman R
Contributing factors include: A diet high in sugar and processed fats[1] Exposure to environmental toxins like air pollution, pesticides and heavy metals[2] Cigarette smoke[3] and alcohol use[4] Infections and chronic inflammation[5] Intense or prolonged physical exertion[6] Psychological stress[7] Biochemically, oxidative stress is marked by an imbalance between oxidants and antioxidants, disrupting cellular signaling, promoting inflammation and weakening mitochondrial function.[8] Over time, this imbalance can lead to cumulative molecular damage, a foundational factor in aging and disease progression

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Thengane SR, Kulkarni DK, Shrikhande VA, Joshi SP, Sonawane KB, Krishnamurthy KV (2003) Influence of medium composition on callus induction and camptothecin(s) accumulation in Nothapodytes foetida
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