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Clinical severity varies widely, depending on the degree to which the synthesis of the affected globin is impaired, altered synthesis of other globin chains, and coinheritance of other abnormal globin alleles

The oxidation of hemoglobin was evaluated by spectrophotometric analysis (500700 nm)

Jimnez E, Marn ML, Martn R, Odriozola JM, Olivares M, Xaus J, et al

Patients who had any combination of the null alleles ( *3 , *4 , *5 , *6 , *52 , or *4xn ) were classified as PM

The Fe-S cluster regulates iron homeostasis in mitochondria

Further, we found a high correlation between the expression of Notch pathway components and SCC-distinguishing metabolic genes (shown in black in Fig