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10.1038/s41583-022-00558-9 65 de MagalhesJ

The three-dimensional (3D) cyclic stretch (10% linear strain, 0.2 Hz) was then initiated via a touchscreen control on the AX Breather, which deflected the microdiaphragm by generating negative cyclic pressure

Results: At baseline, liver biopsy was available in 2687 (91%) patients, in whom 232 (8.6%) had biopsy-proven MASH

To further characterize these interactions, we constructed a molecular interaction network (Figure 7C) revealed three functionally interconnected modules: ( Consistent with multi-omics findings, KEGG pathway analysis identified glutathione metabolism as the most significantly perturbed shared pathway (Figure 8A), exhibiting coordinated changes between upregulated antioxidant enzymes such as Gpx3 and Mgst1 alongside depleted glutathione derivatives, supporting redox imbalance as a key pathogenic feature

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Second, species-specific differences in renal GPX4 biology cannot be excluded, as GPX4 expression has not been characterized in feline kidneys