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Administered via slow intravenous infusion or deep intramuscular injection

When administered late upon infection, higher doses and longer treatment periods may be required due to the presence of overactive T-lymphocyte responses and uncontrolled secretion of proinflammatory cytokines, which might result in irreparable damage (42)

Our recent findings support the notion that 6-paradol, independent of its precursor shogaol, possesses substantial neuroprotective effects

) is one of the most important vegetables in the world, and more than 3.8 million hm 2 of pepper are grown worldwide [16], and peppers tend to accumulate heavy metals during growth, causing toxicity [17]

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The contents of Fe 2+ , Fe 3+ and total iron in the cartilage with OA injury are significantly higher than those in the cartilage without OA injury, suggesting iron deposition occurs in the cartilage during OA progression