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Rhubarb is native to cool, temperate, and subtropical areas in Mongolia, India, and China

Acknowledgements Not applicable Funding Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB)

doi:10.1007/s00018-022-04180-x Pelosi P, Lapi E, Cavalli L, et al

Parenti I, Rabaneda LG, Schoen H, Novarino G

Collectively, these findings support the view that neuroinflammation is not merely an epiphenomenon of depression but a driving force that integrates immune activation with neurotransmitter imbalance, impaired neuroplasticity, and stress-related neuroendocrine dysregulation (30, 31)

Kwok T, Wu Y, Lee J et al (2020) A randomized placebo-controlled trial of using B vitamins to prevent cognitive decline in older mild cognitive impairment patients