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The original fibroblast collagen-synthesis work reported stimulation beginning between 10 -12 and 10 -11 M and peaking at 10 -9 M that is, one nanomolar

Understanding how the microbiome is involved in establishing, maintaining, and reversing obesity has been an active area of research 14,15,16 , and has included studies investigating links between the microbiome and obesity-related comorbidities such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) 17,18

doi: 10.1016/j.freeradbiomed.2013.06.012

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The mTOR pathway in obesity driven gastrointestinal cancers: potential targets and clinical trials