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The investigators interpreted the effects as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in genetic models

References Eliav T, Benoliel R, Korczeniewska OA

Protein Expression Analysis: Evaluating transcriptional and translational responses in controlled laboratory systems

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Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y (2013) Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide