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PGI 2 is a vasodilator and an inhibitor of platelet aggregation, whereas TxA 2 is a vasoconstrictor and a promoter of platelet aggregation [86, 87]

The results elucidated that Clopidogrel induced recurrence of gastric ulcers and inhibited the expression of VEGF-A and VEGFR1 while BPC 157 promoted the healing of ulcers and upregulated both of these proteins, and the L-NAME delayed the gastric ulcer healing through downregulating the VEGF-A and VEGFR1

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This strategy bestowed paclitaxome with an intelligent built-in charge-reversal cationization machinery that selectively triggered adsorption-mediated transcytosis by acidity-induced protonation in tumors, significantly boosting tumor delivery efficiency versus plain paclitaxome, while remaining anionic in physiological condition to avoid protein binding and opsonization 28,50,52

Sobierajska K, Wawro ME, Niewiarowska J