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At the level of thyroid hormone synthesis, TNF- can directly inhibit the activity of thyroid peroxidase (TPO), and IL-1 stimulates iodothyronine 5-deiodine activity in the liver to affect the metabolism of thyroid hormone (Fujii et al., 1989)

tb burden ( Figures 3F, G )

ALA has also been compared with N -acetylcysteine (NAC) in one study, whereby the authors found that NAC is better than ALA in protecting oxidative kidney injury induced by the chemotherapeutic drug ifosfamide, which is highly toxic to the kidney [173,174,175,176]