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401 Additionally, the adoptive transfer of in vitro expanded or genetically engineered CD4 + T cells has emerged as a promising therapeutic approach to rejuvenating immune function in the context of immunosenescence

The young cohort (initially aged 2 months) and mid-old cohort (initially aged 12 months) were established as distinct aging models

where 0.4368 is the average value of E 2( t ) during the cycle (calculated from Panel A of Figure 2)

10.1002/adma.201802244 74 XiongY.-X.XiaoC.LiZ.-F.YangX.-L

B., Wall, B

In vitro studies have shown that Lactobacillus promotes the proliferation and migration of intestinal epithelial cells, regulates the expression of tight junction proteins claudin-1 and occludin, reduces paracellular permeability, and prevents the nuclear translocation of NF-B p65 in intestinal epithelial cells, thereby inhibiting the release of proinflammatory cytokines TNF- and IL-1 (107, 108)