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In summary, these studies in regenerating sensory organs suggest that active Wnt/-catenin signaling can increase the extent of mitotic hair cell regeneration (Figure 4), yet the ability of activating Wnt/-catenin signaling alone to renew proliferation and hair cell regeneration observed in the neonatal, immature mammalian cochlea appears limited in the mature, mammalian cochlea

however, some people have increased intestinal permeability that may allow harmful substances to pass through to the rest of the body, causing uncomfortable GI symptoms

These medications are effective early in their use, but lose efficacy due to the formation of systemic antibodies against them over time

The most severe manifestation is stroke, resulting in varying degrees of neurological deficit

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