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Moreover, elderly women with the estrogen receptor 1 allele exhibit significantly smaller WM lesions, suggesting a protective role of estrogen against age-related WM impairments (Ryan et al., 2014)

However, persistent stimulation leads to the transformation of the inflammatory response from acute to chronic, resulting in neuronal functional impairment and thus facilitates the progression of CNS diseases (1)

Photo by Innerbody Research Nootropics Depot itself claims the silymarin is meant to increase the uptake of berberine, which (like silymarin) has a low bioavailability when taken orally

10.3390/nu11071645 252 ZhangG

There was also a 2x increase in the production of a growth factor that stimulates fibroblasts - basic fibroblast growth factor (bFGF)

2025;73(3):837-848 Beridze G