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This is relevant not only for neuroplasticity but for stress-induced cognitive impairment

2018;13(10):e0206578,1-22

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When patients learn (sometimes the hard way) that using opioids will not give the high they are looking for and can cause 10/10 withdrawal sickness, its clearly not worth the relapse

Due to the comparative small size of the rats and large size of the defects, these defects would fairly mimic large fistulas in patients that would hardly heal spontaneously