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While powerful tools for non-invasive, longitudinal, in vivo assessment, MRI, DTI, and MTR do not allow for microscopic assessment and can be confounded by edema, although this issue is not a particular consideration for the cuprizone model given that vasogenic edema does not play a prominent role

Most likely your medications will have to be adjusted after surgery, most patients require only half of the diabetes medications after surgery

Introduction, minor: As the manuscript does not address optimal dosing schedule (only one dosing schedule is used), perhaps this phrase can be removed

Storage Timeline Lyophilized Solids: Stable at room temperature for up to 4 weeks during transit, but must be transferred to long-term storage at -20C upon receipt