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Neoplasma 45: 312317

The combination of PARP inhibitors with targeted drugs such as ICIs, angiogenesis inhibitors, and tyrosine kinase inhibitors is expected to have positive remedial effects on patients

Activation of SIRT1 improves insulin sensitivity and regulates blood glucose level: SIRT1 can directly deacetylate and activate peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), thereby promoting mitochondrial biogenesis and enhancing cellular energy efficiency, which in turn strengthens tissue responsiveness to insulin [107]

they are the physical manifestations of a cellular engine that is misfiring

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WHO, 2019)