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doi: 10.1038/s41366-024-01678-1 223 PaquetteMEl-HoujeiriLZirdenC LPuustinenPBlanchettePJeongHet al

(Letteria Minutoli)

Doctors must watch patients closely to adjust doses and handle any side effects

For example, non-viral IN pGDNF has been previously delivered via polyelectrolyte complexation with 10-kDa polyethylene-glycol (PEG)-substituted lysine 30-mers (CK30PEG10K) in a rodent model of Parkinsons disease, showing effective transfection while avoiding significant immunogenicity [172]

Further analysis using LEfSe identified Staphylococcus , Arthromitus , Pseudomonas , Mitochondria , Ralstonia , and Chloroplast as discriminatory features of diseased skin, which includes many opportunistic pathogens ( Figure 5G )

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