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The discovery of these biomarkers constitutes a significant advancement in the quest for novel biomarkers that can aid in the early detection of T1D and the monitoring of treatment responses

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21 Iron overload is either the result of dysregulated iron-status signal or erythroid signal and the consequent inadequate hepcidin expression 2, 13, 22 Knowledge regarding the complexities of human iron metabolism has increased significantly in the last two decades and the classification of iron overload diseases has become more detailed as shown in table 1

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