Combinative treatment of -elemene and cetuximab could induce ferroptosis of KRAS-mutant colorectal cancer cells (CRC) by iron-dependent ROS accumulation, GSH depletion, lipid peroxidation, upregulation of HO-1 and transferrin, and downregulation of negative regulatory proteins for ferroptosis (GPX4, SLC7A11, FTH1, glutaminase, and SLC40A1), thus inhibiting tumor growth and lymph node metastases in vivo ( Curcuma zedoaria [Zingiberaceae
These diet shots are non-invasive, with minimal side effects such as mild redness or soreness at the injection site
Serum concentrations of total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), alanine transaminase (ALT), and aspartate aminotransferase (AST) were obtained with a Piccolo Xpress chemistry analyzer (Abaxis, Union City, CA, USA) using lipid panel plus reagent disks (Abaxis #400-1030) for a subset of 10 mice/group
Toxicol Sci 94:217225 Bajt ML, Farhood A, Lemasters JJ, Jaeschke H (2008) Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity
Neutrophils and other phagocytes have formyl peptide receptors (FPR1, FPR2) that bind N-formyl peptides
Allosteric Control of Betaii-Tryptase by a Redox Active Disulfide Bond
