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The ferric heme in the hemoglobin tetramer also causes the remaining normal ferrous hemes within the same tetrameric hemoglobin molecule to have increased O 2 affinity

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A recent study of CRC patients over a 50-month period indicated that 21 of 30 patients with increased miRNA-153 levels also displayed increased metastases, whereas lower miRNA-153 levels were associated with reduced metastasis