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Eventually, the main determinant of brain delivery efficacy is the concentration of the active (parent) drug at site of action in the brain or an increase of the relative distribution of parent drug between the brain and other tissues after administration of prodrug or nanocarriers compared to parent drug dosing

Alcohol entering the tissue can cause stinging, so patience here prevents discomfort

607 In functional studies, astrocytes differentiated from stem cells obtained from familial AD showed aberrant Ca 2+ signalling, 608,609 increased production of reactive oxygen species, reduced lactate supply, compromised neuroprotection, and inability to support neurones in co-cultures

Pasotuxizumab, a BiTE immune therapy for castration-resistant prostate cancer: phase I, dose-escalation study findings

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pmid:28617241