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Since each drug of abuse has a different mechanism of BBB disruption, understanding the effect of polysubstance abuse on BBB could allow the evaluation of novel therapeutic agents and systemic prediction of clinical efficacy

its secondary mass spectrum is shown in Figs

Sglt2 inhibitor luseogliflozin rapidly normalizes aortic mRNA levels of inflammation-related but not lipid-metabolism-related genes and suppresses atherosclerosis in diabetic Apo E KO mice