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The increase in energy demand and calcium turnover that occurs during exercise is sensed by a number of proteins including 5adenosine monophosphateactivated protein kinase (AMPK), mechanistic target of rapamycin (mTOR), Ca 2+/ calmodulindependent protein kinases (CaMKs), sirtuins and mitogenactivated protein kinases (MAPKs) (BasselDuby & Olson, 2006), which activate several key transcription factors, namely PGC1, nuclear respiratory factor (NRF) 1 and 2, and mitochondrial transcription factor A (mtTFA), which regulate mitochondrial biogenesis

Zhao, M., Kim, J

The available evidence suggests that the mechanisms of action of the three peptides are largely paired rather than overlapping, reducing the likelihood of problematic interactions

503 For example, machine learning algorithms such as random forests can assess the importance of different microbial taxa or metabolic pathways to screen out the most discriminating biomarkers

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