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Other key pathological changes include mesangial cell proliferation/hypertrophy, and increased production of extracellular matrix proteins [61, 64, 65]

In line with the finding that expression of IL-2 and the IL-2 receptor CD25 were dampened by SFN, treatment with SFN significantly diminished T-cell proliferation compared to the control cells (Figure 3C, left panel)

(2019) Neurological, psychiatric, and biochemical aspects of thiamine deficiency in children and adults

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Collectively, these findings uncover a metabolic role for the mevalonate pathway in coupling mitochondrial electron transport to amino acid biosynthesis and identify redox imbalance as a key driver of the anti-proliferative effects of statins in cancer cells