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Previous studies have demonstrated that EVs play a role in cell-cell or cell-extracellular space communication by delivering vesicle content, including proteins, nucleic acid or even organelles

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These drugs include monoclonal antibodies targeting Wnts and FZD receptors, molecules inhibiting their secretion and interaction, and small molecule inhibitors that stabilize the -catenin destruction complex and block the binding of -catenin to specific transcription co-activators ( Table 1 )