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Small-molecule inhibitors such as MCC950 have shown efficacy in inhibiting NLRP3 activation and ameliorating liver injury in experimental models of APAP overdose

Stimulation of T cells with GABA also has been shown to inhibit the production of pro-inflammatory cytokines and therefore it attenuates the T cell response in inflammatory disease models such as EAE but also in Diabetes models (Soltani et al., 2011