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While some designations are open to applications from all therapeutic areas, some are specialized to help the advancement of therapies for rare diseases

Megson, Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits, Pharmacol

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Rojo de la Vega et al, 2018)

Other important signaling mechanisms involve Rho and MAP kinases which modulate the expression of proteolytic enzymes, proinflammatory cytokines, autophagy and contractility (29, 30)

The complete absence of glutathione synthesis results in a lethal phenotype (Pasternak et al., 2008)