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In addition, a GSH/GSSG assay kit was used in this study, which is capable of accurately quantifying GSH/GSSG in cells by utilizing the enzymatic reaction between 5, 5-dithiobis-2-nitrobenzoic acid (DTNB) and glutathione reductase (GR)

Similarly, Fortier and colleagues reported that consumption of an MCT-based ketogenic drink for six months elevated ketone body levels and improved cognitive outcomes in subjects with mild cognitive impairment [78]

doi: 10.1016/j.ygeno.2023.110597 42 VoskaridesKGiannopoulouN

When ROS increases, the synthesis of mitochondrial fusion-related proteins will be inhibited, thus promoting mitochondrial fission, which in turn may lead to more ROS production and severe mitochondrial dysfunction

[DOI] [PubMed] [Google Scholar] 6.Vigliani E.C., Baldi G

Fredriksson L, Wink S, Herpers B et al (2014) Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity