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In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

Three studies included data for the occipital cortex and five studies for the medial frontal cortex

[DOI] [PubMed] Ni HM, McGill MR, Chao X, Du K, Williams JA, Xie Y, et al

Drug Metab Dispos 33 , 3137

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