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The negative causal relationships between COX5B, DNAJC19, NDUFB8, and DKA indicate that enhanced functions of these proteins may reduce the risk of DKA by reducing oxidative stress and improving the efficiency of the mitochondrial respiratory chain

This is the fundamental reason that tongue pigmentation matters: it is not just a cosmetic issue, it is sometimes a diagnostic signpost

Clin Neuropharmacol 43:151157

Furthermore, some studies investigated the effect of nutrient combinations

Homocysteine is a well-known redox perturbant and hyperhomocystenemia is known to be associated with redox stress in eukaryotes

Bottom line: While supplements are a powerful tool, lifestyle choices like diet, sleep, and reducing toxic load are essential for maintaining a healthy antioxidant balance