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Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

Symptoms of vitamin B12 deficiency Recently I read, with interest, the book Diagnosis and Management of Hypothyroid by Gordon RB Skinner, MD, who recognises the occurrence of a Vitamin B12 deficiency in many of his patients

Therefore, excessive vitreous degeneration or vitrectomy lowers the concentration of ascorbate in the vitreous, which would be expected to increase the exposure of the lens to oxygen ( Fig