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Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamopituitary disorders: evidence for direct ACTH releasing activity of GHRP-2

Overview of AA metabolism The COX pathway As stated above, the term COX refers to enzymes also known as prostaglandin G/H synthases (PGHS), which metabolize AA to PGH 2 and PHG 2

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doi: 10.1007/s40618-014-0214-2 10 Komosinska-VassevKOlczykKKucharzEJMarciszCWinsz-SzczotkaKKotulskaA

O-HTCC-SOD protected chondrocytes longer than native SOD from monoiodoacetate (MIA)-induced oxidative damage, which included reducing mechanical allodynia, inhibiting gross morphological and histological cartilage lesions, and increasing antioxidant capacity and anti-inflammatory action

(Table 2) To facilitate the translation of mechanistic insights into clinical application, a phased, biomarker-guided approach incorporating preclinical pharmacokinetic studies, early-phase dose-escalation trials, and subsequent long-term randomized controlled trials may help define therapeutic dose ranges, inform safety considerations, and account for interindividual variability