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Enhancing the Oral Bioavailability of Peptide Drugs by using Chemical Modification and Other Approaches

Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress

GM have been shown to produce amyloid, lipopolysaccharide (LPS), or other biological substances that disrupt intestinal homeostasis, affect the central nervous system through the MGB axis, and mediate the pathological process of NDs, such as inflammation, amyloid, and Tau protein accumulation in the brain (Friedland, 2015

Funding Open access funding provided by Universit Paris-Saclay

B.KunzeW

However, they do not clearly slow disease progression and often cause gastrointestinal (GI) side effects like nausea, diarrhea, and vomiting [28]