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Do you remember the model volcano experiment from grade school science class, where you mix baking soda with vinegar and get an eruption of bubbles

The smaller the gauge number, the larger the diameter of the needle

Inhibition of T-type calcium channels

doi:10.1074/jbc.275.12.8982 pmid:10722747 Tait SW, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond

Normally microglia are neuroprotective, cleaning out debris that may contribute to neurodegenerative diseases or damage from ischemic stroke, but in the case of TBI they can become overactivated and exacerbate neuroinflammation (with upregulated TNFa, IL-6, C3, NK-kB, CD68, etc), and vascular changes can result in headaches, neurovascular flow changes, impaired lymphatic flow, blood-brain barrier disruption, activation of pro-inflammatory pathways, neuronal death, hyperexcitability, and disrupted synaptic connections

Notably, no studies to date have specifically tested this hypothesis in patients with Hashimotos thyroiditis, limiting the generalisability of existing evidence to this particular population