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While co-translational activity of METAP2 is independent of the NAC complex, METAP1 relies on the hydrophobic motif in the NACB C-terminus 25

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Breathing oxygen at a pressure of 2.8 ATA increases hemoglobin oxygenation (from 83 to 88%), cerebral blood flow, and regional cerebral oxygenation ( Details of molecular mechanisms of neuroprotective HBOT effects come mainly from limited publications on animal models of neonatal HI, focusing on alterations caused by cerebral hypoxia or the antioxidant factors in the newborn blood

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