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Although most studies had described the beneficial effects of curcumin in PD, a few contradictory reports had shown that curcumin actually exacerbated the disease, notably in a study by Ortiz-Ortiz et al ., [380] which showed higher apoptosis rate in N27 mesencephalic cells after co-incubation in curcumin and paraquat

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Glutathione is naturally present throughout the body, including within the gastrointestinal system, and plays a role in maintaining normal cellular and antioxidant processes

Notably, researchers have identified endogenous progenitor cells in multiple regions of the intervertebral disc, including the nucleus pulposus, annulus fibrosus, and endplate (Shen et al., 2015)

For the polymerization step, COs were transferred to a Been embedding capsule and polymerized at 60 o C for 48 h