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A first-in-patient study (NCT01937689) of 38 HER2 + MBC patients determined the maximum tolerated dose of pyrotinib to be 400 mg once per day

SHMT catalyzes the conversion of serine to glycine and is regulated by c-MYC , an oncogene that controls the transcription of 15% of human genes [123, 137, 138]

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The biosynthetic pathway for lipoproteins, present both in Gram-negative and Gram-positive bacteria with high GC content, consists of the following three reactions (Fig

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Moreover, a GWAS has linked specific risk variants associated with glutamate metabolism to increased cortical glutamate concentrations and poor disease outcomes in MS patients (91)