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We also note for the commenter that section 1848(c)(7) of the Act, as added by section 220(e) of the PAMA, specifies that for services that are not new or revised codes, if the total RVUs for a service for a year would otherwise be decreased by an estimated 20 percent or more as compared to the total RVUs for the previous year, the applicable adjustments in work, PE, and MP RVUs shall be phased-in over a 2-year period

Response: We designed the APCM code set, including the practice-level performance measurement requirement, for purposes of payment under FFS Medicare

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Second, FGF21 suppresses TGF- release from pro-inflammatory macrophages in vitro (177), which would be expected to reduce Kupffer cell activation of HSCs in vivo