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Transcripts were reconstructed using StringTie (v2.1.0) based on HISAT2 (v2.1.0) alignment, and gene expression levels were calculated using RSEM (v1.2.19) and quantified as FPKM (Fragments Per Kilobase of transcript per Million mapped reads)

LR3 IGF-1 binds poorly to IGF binding proteins (IGFBPs), giving it a circulating half-life of roughly 20-30 hours versus minutes for native IGF-1 (Tomas et al., 1993)

NAMPT allows recycling of the NAM produced through the activities of NAD + -consuming enzymes into NAD +

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