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Surgical lens extraction remains the standard treatment, which, despite its effectiveness, carries potential postoperative risks and economic burdens, thereby underscoring the need for alternative, non-surgical therapeutic approaches

However, the clinical effectiveness of these approaches remains to be determined

All participants received 600 mg ALA orally per day for 4 weeks and were instructed not to receive any drug that relieves neuropathic pain

Unfortunately, the prognosis remains poor, with a median overall survival (mOS) of 20.9 months and a median progression-free survival (mPFS) of 6.7 months ( Here, we will discuss the previously explored repurposing efforts in the treatment of GB based on targeting two of the three most altered signal transduction pathways in GB: Receptor tyrosine kinase (RTK) and cyclin-dependent kinase (CDK)-retinoblastoma (Rb) ( Despite an increased understanding of GB tumor biology with discoveries of potential targets, the unique challenges posed by this aggressive tumor continue to thwart treatment benefits

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