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Variability of ALT ULN can affect eDISHs function as a DILI screening tool and DILI assessment in clinical rials may benefit from standardized, uniform TB ULN and lower fixed ALT ULN

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Statements Author contributions MN and SB contributed writing as well as the organization and idea to the work

Besides that, quercetin can revert gut microbiota imbalance and TLR-4 pathway induction mediated by endotoxemia, and then subsequently inhibit inflammasome response and reticulum stress pathway activation, leading to the blockage of lipid metabolism and gene expression deregulation, which helps to alleviate NAFLD in HFD mice [38]

Globally, various studies reveal the prevalence of undiagnosed DPN, with alarming percentages even reaching 99.8%

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