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A comparison of the methodologies reveals that both studies generated microglia-specific TRPM2 knockout mice by crossing Trpm2 fl/fl mice with Cx3cr1CreER mice

None of this means supplementation "doesn't work" for these groups it means the realistic timeline may sit toward the longer end of the 8-12 week range, or occasionally extend a few weeks beyond it, rather than indicating product failure

Where BPC-157 drives local repair and angiogenesis and TB-500 supports systemic cell migration, KPV calms the inflammation that accompanies injury and gut irritation

doi: 10.1186/s12934-020-01351-y

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