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IV administration might be chosen if you are already on IV fluids or need a very rapid correction of vitamin levels

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First, the amount of dopamine and serotonin produced will suddenly drop and so now the person, who has already down-regulated receptor production will suddenly have too few receptors to respond to the greatly reduced amount of dopamine and serotonin and so may experience extreme depression, in a similar fashion to any drug addict coming off medication

Vitamin B12 needs the stomach and intestines to work together to absorb it properly

doi:10.1186/1756-8722-1-26 20