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Unlike apoptosis, paraptosis does not hinge on caspase activity but frequently hinges on the activation of mitogen-activated protein kinases (MAPKs), such as MAPK8/JNK, MAPK14/p38, and mitogen-activated protein kinase kinase 2 (MAP2K2/MEK2) [148]

Zinc plays a critical role in the cardioprotective effect of postconditioning by enhancing the activation of the RISK pathway in rat hearts

At the same time, it has been hypothesized that autophagy pathways involved in lysophagy in non-erythroid cells, e.g., the p62-mediated pathway [67], might be responsible for the clearance of lysosomes in the erythroid lineage as well [51]