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L-Carnitine exhibits cardioprotective properties through multiple pathways including reduction of oxidative stress, improvement of mitochondrial bioenergetics, and modulation of inflammatory responses

The third PSG parameter was change in the number of nocturnal awakenings per night, defined as a PSG recording of 2 consecutive wake epochs, separated by an epoch of N2, N3, or REM (i.e., separation by stage N1 did not denote a new awakening), and were counted from first epoch of sleep to lights on

Global, regional, and national burden of ischaemic heart disease and its attributable risk factors, 19902017: results from the Global Burden of Disease Study 2017

Sep 1998;13(9):2241-2247

J.ElkordE

Clinical studies have demonstrated that curcumin inhibits NLRP3 inflammasome activation via NF-B-induced P2X7R signalling in macrophages (Kong et al., 2016), and apigenin significantly reduces the mRNA and protein expression of TMAO-induced NLRP3 (Yamagata et al., 2019), which suggests that TCM could potentially treat CRC by impacting the NLRP3 inflammasome, providing a potential pathway